A recent study indicates that individuals who come off blockbuster GLP-1 drugs like semaglutide or tirzepatide can put back on lost weight far faster than those who stop traditional diet and exercise regimens.
Research printed in a prominent medical journal shows that while overweight individuals often shed substantial amounts of their body weight while using the jabs, the mass comes back at an average rate of nearly a kilo each month upon discontinuation.
"Individuals purchasing these drugs need to be aware of the potential of quick weight regain when the therapy is stopped," warns lead investigator Dr. Susan Jebb.
That rate of regain means a return to pre-treatment mass within about 18 months.
Analyzing Therapies
The study, which reviewed 37 of trials involving over 9,000 of participants, contrasted the effects of these new drugs with older methods.
Scientists point out that individuals who shed pounds through diet and exercise generally see a more gradual weight regain—around 100 grams monthly—once they finish.
Explaining the Quick Regain
Doctors believe the way of the jabs accounts for the amplified regain.
GLP-1 drugs imitate a body's own chemical called glucagon-like peptide-1, which moderates hunger.
"Artificially providing the hormone concentrations several times higher than normal could lead to the body to produce less of its endogenous GLP-1, and could reduce sensitivity to its effects," said Dr. Adam Collins, a nutrition specialist.
"Withdrawal of this medication means hunger is unsuppressed, making excessive eating far more likely."
A Lifelong Issue?
Health authorities recommend the injections for people with obesity-related health risks, accompanied by recommended lifestyle changes.
Many experts contend that, due to the high risk of relapse, the treatment is often long-term.
This opinion is reinforced by pharmaceutical companies, who state that the findings "underscore the long-term character of excess weight," comparing it to managing conditions like diabetes.
Patient Experiences
People who have discontinued the jabs explain a sudden return of hunger.
"It felt as if something that goes on and you become starving," described a patient.
This challenge is compounded if individuals have not developed permanent dietary or behavioural modifications during therapy.
Widespread Interest
Survey data indicate that millions of adults in the UK have used weight-loss jabs in the past year, with demand being substantial.
- Use is higher among women compared to males.
- The 40s and 50s age group shows the greatest level of interest.
- A large proportion access the medications through private healthcare rather than the NHS.
Finally, researchers caution that while the jabs are powerful agents for weight loss, they are not a magic cure and maintained weight loss likely depends on ongoing lifestyle changes.
